New complexities for BRCA1 and BRCA2

New complexities for BRCA1 and BRCA2

A large number of diverse functions have been attributed to the BRCA1 and BRCA2 breast cancer susceptibility genes. Here we review recent progress in the field.

BRCA1 and BRCA2

But isn't inherited breast cancer quite rare? Well of course most breast cancers aren’t hereditary. Inherited predisposition accounts for about 5% of all breast cancers — mutations in BRCA1 and BRCA2 probably cause a significant proportion of these. So BRCA mutation doesn’t cause a high fraction of all breast cancers, but, because this disease is so common (about 1 in 10 lifetime risk), it adds...

Genetic testing for BRCA1 and BRCA2 genes.

نقش ژن‌های BRCA1 و BRCA2 در ابتلاء به سرطان پستان

مقدمه: جهش‌های ژنی BRCA1 و BRCA2 در سلول‌های رده زایا، باعث خطر ابتلاء به سرطان پستان و تخمدان می‌شوند. ژن‌های BRCA1 و BRCA2، عامل 20% از موارد سرطان پستان ارثی هستند. اکثریت جهش‌های موجود در ژن‌های BRCA1 و BRCA2 باعث اتمام زودرس پروتئین می‌شوند. مطالعه حاضر با هدف بررسی نقش جهش‌های BRCA1/2 در ابتلاء به سرطان پستان و معرفی برخی جهش‌های مرتبط با این ژن‌ها انجام شد. روش‌کار: در این مطالعه مروری س...

Meta-analysis of BRCA1 and BRCA2 penetrance.

PURPOSE Genetic counseling is now routinely offered to individuals at high risk of carrying a BRCA1 or BRCA2 mutation. Risk prediction provided by the counselor requires reliable estimates of the mutation penetrance. Such penetrance has been investigated by studies worldwide. The reported estimates vary. To facilitate clinical management and counseling of the at-risk population, we address this...